Charles Jayne

Charles Jayne

Central US Merck & Co., Inc. - Kenilworth / United States
Natural Sciences / Chemical Sciences
AD Scientific Index ID: 5680860
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person_outline Charles Jayne's MOST POPULAR ARTICLES
1-) Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetesY Xia, S Chackalamannil, WJ Greenlee, C Jayne, B Neustadt, A Stamford, ...Bioorganic & medicinal chemistry letters 21 (11), 3290-3296, 2011442011
2-) Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in RodentsGL Adams, F Velazquez, C Jayne, U Shah, S Miao, ER Ashley, M Madeira, ...ACS Medicinal Chemistry Letters 8 (1), 96-101, 2017332017
3-) Discovery of MK-8831, a novel spiro-proline macrocycle as a pan-genotypic HCV-NS3/4a protease inhibitorSF Neelamkavil, S Agrawal, T Bara, C Bennett, S Bhat, D Biswas, ...ACS Medicinal Chemistry Letters 7 (1), 111-116, 2016332016
4-) Novel quinoline-based P2–P4 macrocyclic derivatives as pan-genotypic HCV NS3/4a protease inhibitorsU Shah, C Jayne, S Chackalamannil, F Velázquez, Z Guo, A Buevich, ...ACS medicinal chemistry letters 5 (3), 264-269, 2014312014
5-) Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119Y Xia, CD Boyle, WJ Greenlee, S Chackalamannil, CL JayneUS Patent 8,907,095, 2014242014