Fabrice Pierre

Fabrice Pierre

Vertex Pharmaceuticals - Boston / United States
Natural Sciences / Chemical Sciences
AD Scientific Index ID: 4613997
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person_outline Fabrice Pierre's MOST POPULAR ARTICLES
1-) CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacyA Siddiqui-Jain, D Drygin, N Streiner, P Chua, F Pierre, SE O\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'Brien, ...Cancer research 70 (24), 10288-10298, 20104882010
2-) Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for …F Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ...Journal of medicinal chemistry 54 (2), 635-654, 20112882011
3-) Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancerR Battistutta, G Cozza, F Pierre, E Papinutto, G Lolli, S Sarno, SE O’Brien, ...Biochemistry 50 (39), 8478-8488, 20111602011
4-) Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancerF Pierre, PC Chua, SE O’Brien, A Siddiqui-Jain, P Bourbon, M Haddach, ...Molecular and cellular biochemistry 356 (1), 37-43, 20111752011
5-) Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeuticsM Haddach, MK Schwaebe, J Michaux, J Nagasawa, SE O\'Brien, ...ACS medicinal chemistry letters 3 (7), 602-606, 20121602012