Jayasankar Jasti

Jayasankar Jasti

Pfizer Inc. - New York / United States
Natural Sciences / Biological Science
AD Scientific Index ID: 4397638
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person_outline Jayasankar Jasti's MOST POPULAR ARTICLES
1-) Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pHJ Jasti, H Furukawa, EB Gonzales, E GouauxNature 449 (7160), 316-323, 200711342007
2-) Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant …JL Henderson, BL Kormos, MM Hayward, KJ Coffman, J Jasti, ...Journal of medicinal chemistry 58 (1), 419-432, 20151562015
3-) First structural evidence of a specific inhibition of phospholipase A2 by α-tocopherol (vitamin E) and its implications in inflammation: Crystal structure of the complex formed …V Chandra, J Jasti, P Kaur, C Betzel, A Srinivasan, TP SinghJournal of molecular biology 320 (2), 215-222, 20021552002
4-) Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 Å Crystal Structure,V Chandra, J Jasti, P Kaur, A Srinivasan, C Betzel, TP SinghBiochemistry 41 (36), 10914-10919, 2002882002
5-) Discovery of PF-06835919: a potent inhibitor of ketohexokinase (KHK) for the treatment of metabolic disorders driven by the overconsumption of fructoseK Futatsugi, AC Smith, M Tu, B Raymer, K Ahn, SB Coffey, MS Dowling, ...Journal of Medicinal Chemistry 63 (22), 13546-13560, 2020562020