Lisa Shewchuk

Lisa Shewchuk

GlaxoSmithKline - Needham / United Kingdom
Others
AD Scientific Index ID: 4370876
-
person_outline Lisa Shewchuk's MOST POPULAR ARTICLES
1-) A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib) relationships among protein conformation, inhibitor off-rate, and receptor activity in …ER Wood, AT Truesdale, OB McDonald, D Yuan, A Hassell, SH Dickerson, ...Cancer research 64 (18), 6652-6659, 200412332004
2-) Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and …JM Axten, JR Medina, Y Feng, A Shu, SP Romeril, SW Grant, WHH Li, ...Journal of medicinal chemistry 55 (16), 7193-7207, 20125542012
3-) Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin-and DNA-binding domains.KP Wilson, LM Shewchuk, RG Brennan, AJ Otsuka, BW MatthewsProceedings of the National Academy of Sciences 89 (19), 9257-9261, 19923641992
4-) Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysisHN Bramson, J Corona, ST Davis, SH Dickerson, M Edelstein, SV Frye, ...Journal of medicinal chemistry 44 (25), 4339-4358, 20013142001
5-) The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathwayKD Baker, LM Shewchuk, T Kozlova, M Makishima, A Hassell, B Wisely, ...Cell 113 (6), 731-742, 20032942003