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Scott J Hughes
University of Dundee - Dundee / United Kingdom
Medical and Health Sciences / Biochemistry
AD Scientific Index ID: 1342888
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Scott J Hughes's MOST POPULAR ARTICLES
1-)
Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) based …V Zoppi, SJ Hughes, C Maniaci, A Testa, T Gmaschitz, C Wieshofer, ...Journal of medicinal chemistry 62 (2), 699-726, 20181862018
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SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rateMJ Roy, S Winkler, SJ Hughes, C Whitworth, M Galant, W Farnaby, ...ACS chemical biology 14 (3), 361-368, 20192772019
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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradationC Maniaci, SJ Hughes, A Testa, W Chen, DJ Lamont, S Rocha, DR Alessi, ...Nature Communications 8 (1), 830, 20172742017
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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degradersSJ Hughes, A CiulliEssays in biochemistry 61 (5), 505-516, 20172122017
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Structure‐based design of a macrocyclic PROTACA Testa, SJ Hughes, X Lucas, JE Wright, A CiulliAngewandte Chemie 132 (4), 1744-1751, 20202042020
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